PF00995

Sec1 family

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSec1
Author Bateman A;0000-0002-6982-4660 Griffiths-Jones SR;0000-0001-6043-807X
Sequence Ontology0100021

Description
Imported from IPR001619

Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis
[2]
. They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation, a protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events, their interaction with syntaxin molecules seems to represent a negative regulatory step in secretion
[1]
.

References
Imported from IPR001619

1.The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis. Bracher A, Perrakis A, Dresbach T, Betz H, Weissenhorn W. Structure 8, 685-94, (2000). View articlePMID: 10903948

2.The Sec1 family: a novel family of proteins involved in synaptic transmission and general secretion. Halachmi N, Lev Z. J. Neurochem. 66, 889-97, (1996). PMID: 8769846

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