Member database | Pfam |
Pfam type | family |
Short name | Crust_neurohorm |
Author | Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description Imported from IPR031098
* Crustacean hyperglycemic hormone (CHH). CHH is primarily involved in blood sugar regulation, but also plays a role in the control of molting and reproduction.
* Molt-inhibiting hormone (MIH). MIH inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops.
* Gonad-inhibiting hormone (GIH), also known as vitellogenesis-inhibiting hormone (VIH) because of its role in inhibiting vitellogenesis in female animals.
* Mandibular organ-inhibiting hormone (MOIH). MOIH represses the synthesis of methyl farnesoate, the precursor of insect juvenile hormone III in the mandibular organ.
* Ion transport peptide (ITP) from locust. ITP stimulates salt and water reabsorption and inhibits acid secretion in the ileum of the locust.
These neurohormones are peptides of 70 to 80 residues which are processed from larger size precursors. They contain six conserved cysteines that are involved in disulphide bonds, as shown in the following schematic representation.
References Imported from IPR031098
1.Molecular biology of neurohormone precursors in the eyestalk of Crustacea. De Kleijn DP, Van Herp F. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 112, 573-9, (1995). View articlePMID: 8590372
2.Recruitment and diversification of an ecdysozoan family of neuropeptide hormones for black widow spider venom expression. McCowan C, Garb JE. Gene 536, 366-75, (2014). View articlePMID: 24316130
3.The cloning of a cDNA encoding a protein (latrodectin) which co-purifies with the alpha-latrotoxin from the black widow spider Latrodectus tredecimguttatus (Theridiidae). Pescatori M, Bradbury A, Bouet F, Gargano N, Mastrogiacomo A, Grasso A. Eur. J. Biochem. 230, 322-8, (1995). View articlePMID: 7601118
4.Structure of the low molecular weight protein copurified with alpha-latrotoxin. Kiyatkin N, Dulubova I, Chekhovskaya I, Lipkin A, Grishin E. Toxicon 30, 771-4, (1992). View articlePMID: 1509496