Member database | Pfam |
Pfam type | domain |
Short name | Fapy_DNA_glyco |
Author | Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges
[1].
References
1.Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA. Gilboa R, Zharkov DO, Golan G, Fernandes AS, Gerchman SE, Matz E, Kycia JH, Grollman AP, Shoham G. J. Biol. Chem. 277, 19811-6, (2002). View articlePMID: 11912217