PF01149

Formamidopyrimidine-DNA glycosylase N-terminal domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameFapy_DNA_glyco
Author Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges
[1]
.

References

1.Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA. Gilboa R, Zharkov DO, Golan G, Fernandes AS, Gerchman SE, Matz E, Kycia JH, Grollman AP, Shoham G. J. Biol. Chem. 277, 19811-6, (2002). View articlePMID: 11912217

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