PF01166

TSC-22/dip/bun family

Pfam entry
Member databasePfam
Pfam typecoiled coil
Short nameTSC22
Author Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660
Sequence Ontology0001080

Description
Imported from IPR000580

This entry includes a group of eukaryotic proteins that are evolutionary related and involved in transcriptional regulation. These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerisation. Proteins included in this entry are:


 * Vertebrate proteins TSC22 1-4
[2, 1]
, transcriptional regulators that act in different pathways, for instance, TSC22-1 acts on C-type natriuretic peptide (CNP) promoter
[2]
, it also promotes CASP3-mediated apoptosis
[4]
and positively regulates TGF-beta signaling
[5]
; TSC22-3 (also known as DIP) protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11
[6]
and it also contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4
[7]
.
 * Drosophila protein bunched
[3]
(gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
 * Caenorhabditis elegans protein tsct-1 (also known as T18D3.7), whose function is unknown.

References
Imported from IPR000580

1.Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B. J Biol Chem 274, 27439-47, (1999). PMID: 10488076

2.Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. Ohta S, Shimekake Y, Nagata K. Eur. J. Biochem. 242, 460-6, (1996). View articlePMID: 9022669

3.Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. Treisman JE, Lai ZC, Rubin GM. Development 121, 2835-45, (1995). View articlePMID: 7555710

4.Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22. Lee JH, Rho SB, Park SY, Chun T. FEBS Lett 582, 1210-8, (2008). PMID: 18325344

5.TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG. Mol Cell Biol 31, 3700-9, (2011). PMID: 21791611

6.GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. Asselin-Labat ML, David M, Biola-Vidamment A, Lecoeuche D, Zennaro MC, Bertoglio J, Pallardy M. Blood 104, 215-23, (2004). PMID: 15031210

7.Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. Choi SJ, Moon JH, Ahn YW, Ahn JH, Kim DU, Han TH. Mol Cell Biochem 271, 23-8, (2005). PMID: 15881652

Further reading

8. hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues. Vogel P, Magert HJ, Cieslak A, Adermann K, Forssmann WG. Biochim. Biophys. Acta 1309, 200-4, (1996). View articlePMID: 8982256

9. The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Dobens LL, Hsu T, Twombly V, Gelbart WM, Raftery LA, Kafatos FC. Mech Dev 65, 197-208, (1997). PMID: 9256356

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