Member database | Pfam |
Pfam type | coiled coil |
Short name | TSC22 |
Author | Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0001080 |
Description Imported from IPR000580
* Vertebrate proteins TSC22 1-4
* Drosophila protein bunched
* Caenorhabditis elegans protein tsct-1 (also known as T18D3.7), whose function is unknown.
References Imported from IPR000580
1.Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B. J Biol Chem 274, 27439-47, (1999). PMID: 10488076
2.Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. Ohta S, Shimekake Y, Nagata K. Eur. J. Biochem. 242, 460-6, (1996). View articlePMID: 9022669
3.Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. Treisman JE, Lai ZC, Rubin GM. Development 121, 2835-45, (1995). View articlePMID: 7555710
4.Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22. Lee JH, Rho SB, Park SY, Chun T. FEBS Lett 582, 1210-8, (2008). PMID: 18325344
5.TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG. Mol Cell Biol 31, 3700-9, (2011). PMID: 21791611
Further reading
8. hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues. Vogel P, Magert HJ, Cieslak A, Adermann K, Forssmann WG. Biochim. Biophys. Acta 1309, 200-4, (1996). View articlePMID: 8982256
9. The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Dobens LL, Hsu T, Twombly V, Gelbart WM, Raftery LA, Kafatos FC. Mech Dev 65, 197-208, (1997). PMID: 9256356