Member database | Pfam |
Pfam type | family |
Short name | Methyltr_RsmB-F |
Clan | NADP_Rossmann |
Author | Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description
This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme
[2, 1]. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA
[2, 1].
References
1.Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Demirci H, Larsen LH, Hansen T, Rasmussen A, Cadambi A, Gregory ST, Kirpekar F, Jogl G. RNA 16, 1584-96, (2010). View articlePMID: 20558545
2.Crystal structure of human p120 homologue protein PH1374 from Pyrococcus horikoshii. Ishikawa I, Sakai N, Tamura T, Yao M, Watanabe N, Tanaka I. Proteins 54, 814-6, (2004). View articlePMID: 14997580