PF01189

16S rRNA methyltransferase RsmB/F

Pfam entry
Member databasePfam
Pfam typefamily
Short nameMethyltr_RsmB-F
ClanNADP_Rossmann
Author Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme
[2, 1]
. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA
[2, 1]
.

References

1.Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Demirci H, Larsen LH, Hansen T, Rasmussen A, Cadambi A, Gregory ST, Kirpekar F, Jogl G. RNA 16, 1584-96, (2010). View articlePMID: 20558545

2.Crystal structure of human p120 homologue protein PH1374 from Pyrococcus horikoshii. Ishikawa I, Sakai N, Tamura T, Yao M, Watanabe N, Tanaka I. Proteins 54, 814-6, (2004). View articlePMID: 14997580

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