PF01323

DSBA-like thioredoxin domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDSBA
ClanThioredoxin
Author Bateman A;0000-0002-6982-4660 Mifsud W;0000-0002-9805-6461
Sequence Ontology0000417

Description

This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways
[3, 1, 4]
. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised. The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see
[2]
).

References

1.Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid. Eaton RW. J. Bacteriol. 176, 7757-62, (1994). View articlePMID: 8002605

2.Identification of a gene for a chemoreceptor of the methyl-accepting type in the symbiotic plasmid of Rhizobium leguminosarum bv. viciae UPM791. Brito B, Palacios JM, Ruiz-Argueso T, Imperial J. Biochim. Biophys. Acta 1308, 7-11, (1996). View articlePMID: 8765742

3.Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway. Denome SA, Stanley DC, Olson ES, Young KD. J. Bacteriol. 175, 6890-901, (1993). View articlePMID: 8226631

4.The phn genes of Burkholderia sp. strain RP007 constitute a divergent gene cluster for polycyclic aromatic hydrocarbon catabolism. Laurie AD, Lloyd-Jones G. J. Bacteriol. 181, 531-40, (1999). View articlePMID: 9882667

Further reading

5. Structure of TcpG, the DsbA protein folding catalyst from Vibrio cholerae. Hu SH, Peek JA, Rattigan E, Taylor RK, Martin JL. J. Mol. Biol. 268, 137-46, (1997). View articlePMID: 9149147

Wikipedia

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