PF01401

Angiotensin-converting enzyme

Pfam entry
Member databasePfam
Pfam typefamily
Short namePeptidase_M2
ClanPeptidase_MA
Author Bateman A;0000-0002-6982-4660 Coates D;
Sequence Ontology0100021

Description

Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.

References

1. Peptidyl dipeptidase A: angiotensin I-converting enzyme. Corvol P, Williams TA, Soubrier F. Meth. Enzymol. 248, 283-305, (1995). View articlePMID: 7674927

2. Toward a role for angiotensin-converting enzyme in insects. Isaac RE, Schoofs L, Williams TA, Corvol P, Veelaert D, Sajid M, Coates D. Ann. N. Y. Acad. Sci. 839, 288-92, (1998). View articlePMID: 9629165

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