Member database | Pfam |
Pfam type | family |
Short name | Peptidase_M2 |
Clan | Peptidase_MA |
Author | Bateman A;0000-0002-6982-4660 Coates D; |
Sequence Ontology | 0100021 |
Description
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
References
1. Peptidyl dipeptidase A: angiotensin I-converting enzyme. Corvol P, Williams TA, Soubrier F. Meth. Enzymol. 248, 283-305, (1995). View articlePMID: 7674927
2. Toward a role for angiotensin-converting enzyme in insects. Isaac RE, Schoofs L, Williams TA, Corvol P, Veelaert D, Sajid M, Coates D. Ann. N. Y. Acad. Sci. 839, 288-92, (1998). View articlePMID: 9629165
Integrated to
Representative structure
2xy9: Human Angiotensin converting enzyme in complex with phosphinic tripeptide