PF01415

Interleukin 7

Pfam entry
Member databasePfam
Pfam typedomain
Short nameIL7
Clan4H_Cytokine
Author Ponting CP;0000-0003-0202-7816 Schultz J; Bork P;0000-0002-2627-833X El-Gebali S;0000-0003-1378-5495
Sequence Ontology0000417

Description

IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells
[1]
[2]
.

References

1.The tertiary structure of γc cytokines dictates receptor sharing. Reche PA. Cytokine 116, 161-168, (2019). PMID: 30716660

2.Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. McElroy CA, Dohm JA, Walsh ST. Structure 17, 54-65, (2009). View articlePMID: 19141282

Wikipedia

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