Member database | Pfam |
Pfam type | domain |
Short name | PLAT |
Clan | PLAT |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.