PF01479

S4 domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameS4
ClanS4
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation
[1]
. The S4 domain probably mediates binding to RNA.

References

1.Novel predicted RNA-binding domains associated with the translation machinery. Aravind L, Koonin EV. J. Mol. Evol. 48, 291-302, (1999). View articlePMID: 10093218

Further reading

2. The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif. Davies C, Gerstner RB, Draper DE, Ramakrishnan V, White SW. EMBO J. 17, 4545-58, (1998). View articlePMID: 9707415

Wikipedia

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