PF01487

Type I 3-dehydroquinase

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDHquinase_I
ClanTIM_barrel
Author Bashton M;0000-0002-6847-1525 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220.

References

1. The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L. Nat. Struct. Biol. 6, 521-5, (1999). View articlePMID: 10360352

2. The molecular biology of multidomain proteins. Selected examples. Hawkins AR, Lamb HK. Eur. J. Biochem. 232, 7-18, (1995). View articlePMID: 7556173

Wikipedia

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