Member database | Pfam |
Pfam type | family |
Short name | TruB_N |
Clan | PseudoU_synth |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description
Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA
[1].
References
1.The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Lafontaine DL, Bousquet-Antonelli C, Henry Y, Caizergues-Ferrer M, Tollervey D. Genes Dev. 12, 527-37, (1998). View articlePMID: 9472021
Further reading
2. Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli. Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J. RNA 1, 102-12, (1995). View articlePMID: 7489483