PF01509

TruB family pseudouridylate synthase (N terminal domain)

Pfam entry
Member databasePfam
Pfam typefamily
Short nameTruB_N
ClanPseudoU_synth
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA
[1]
.

References

1.The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Lafontaine DL, Bousquet-Antonelli C, Henry Y, Caizergues-Ferrer M, Tollervey D. Genes Dev. 12, 527-37, (1998). View articlePMID: 9472021

Further reading

2. Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli. Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J. RNA 1, 102-12, (1995). View articlePMID: 7489483

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