PF01512

Respiratory-chain NADH dehydrogenase 51 Kd subunit

Pfam entry
Member databasePfam
Pfam typefamily
Short nameComplex1_51K
ClanHybrid
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description
Imported from IPR011538

This entry represents the FMN-binding domain of NADH-ubiquinone oxidoreductase 51kDa subunit from NADH:ubiquinone oxidoreductase.

Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51kDa (in mammals), which is the second largest subunit of complex I
[1]
. The 51kDa subunit, as the corresponding bacterial subunit (Nqo1 in Thermus and NuoF in E. coli)
[2]
, contains the NADH-binding site, the primary electron acceptor FMN-binding site, and a 4Fe-4S cluster
[3]
.

References
Imported from IPR011538

1.The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. Weiss H, Friedrich T, Hofhaus G, Preis D. Eur. J. Biochem. 197, 563-76, (1991). View articlePMID: 2029890

2.The proton-translocating NADH-quinone oxidoreductase in the respiratory chain: the secret unlocked. Yagi T, Matsuno-Yagi A. Biochemistry 42, 2266-74, (2003). View articlePMID: 12600193

3.Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Sazanov LA, Hinchliffe P. Science 311, 1430-6, (2006). View articlePMID: 16469879

Further reading

4. The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. Walker JE. Q. Rev. Biophys. 25, 253-324, (1992). PMID: 1470679

5. Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). Schneider D, Pohl T, Walter J, Dorner K, Kohlstadt M, Berger A, Spehr V, Friedrich T. Biochim. Biophys. Acta 1777, 735-9, (2008). View articlePMID: 18394423

6. The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases. Friedrich T, Scheide D. FEBS Lett. 479, 1-5, (2000). View articlePMID: 10940377

Wikipedia

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