PF01694

Rhomboid family

Pfam entry
Member databasePfam
Pfam typefamily
Short nameRhomboid
ClanRhomboid-like
AuthorSohrmann M; Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease
[4]
[2]
[3]
(EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite
[1]
.

References

1.A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Brossier F, Jewett TJ, Sibley LD, Urban S. Proc. Natl. Acad. Sci. U.S.A. 102, 4146-51, (2005). View articlePMID: 15753289

2.The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L. Genome Biol. 4, R19, (2003). View articlePMID: 12620104

3.Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Urban S, Wolfe MS. Proc. Natl. Acad. Sci. U.S.A. 102, 1883-8, (2005). View articlePMID: 15684070

4.Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Urban S, Lee JR, Freeman M. Cell 107, 173-82, (2001). View articlePMID: 11672525

Further reading

5. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Bier E, Jan LY, Jan YN. Genes Dev. 4, 190-203, (1990). View articlePMID: 2110920

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