PF01916

Deoxyhypusine synthase

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDS
ClanNADP_Rossmann
Author Enright A;0000-0002-6090-3100 Ouzounis C;0000-0002-0086-8657 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation
[1]
.

References

1.Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Liao DI, Wolff EC, Park MH, Davies DR. Structure 6, 23-32, (1998). View articlePMID: 9493264

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