Member database | Pfam |
Pfam type | family |
Short name | TraB_PrgY_gumN |
Clan | TIKI |
Author | Enright A;0000-0002-6090-3100 Ouzounis C;0000-0002-0086-8657 Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description
This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities
[2]. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors
[1, 2]. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone
[2].
References
1.The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa? Bazan JF, Macdonald BT, He X. Dev. Cell 25, 225-7, (2013). PMID: 23673329
2.Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Cell 149, 1565-77, (2012). View articlePMID: 22726442