PF02025

Interleukin 5

Pfam entry
Member databasePfam
Pfam typedomain
Short nameIL5
Clan4H_Cytokine
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description
Imported from IPR000186

This entry represents interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF), is a lineage-specific cytokine for eosinophilpoiesis
[1, 2]
. It regulates eosinophil growth and activation
[1]
, and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma
[2]
. IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF)
[2]
, but while these exist as monomeric structures, IL5 is a homodimer. The fold contains an anti-parallel 4-α-helix bundle with a left handed twist, connected by a 2-stranded anti-parallel β-sheet
[2, 3]
. The monomers are held together by 2 interchain disulphide bonds
[3]
.

References
Imported from IPR000186

1.Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Campbell HD, Tucker WQ, Hort Y, Martinson ME, Mayo G, Clutterbuck EJ, Sanderson CJ, Young IG. Proc. Natl. Acad. Sci. U.S.A. 84, 6629-33, (1987). View articlePMID: 3498940

2.A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Milburn MV, Hassell AM, Lambert MH, Jordan SR, Proudfoot AE, Graber P, Wells TN. Nature 363, 172-6, (1993). View articlePMID: 8483502

3.Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein. Proudfoot AE, Davies JG, Turcatti G, Wingfield PT. FEBS Lett. 283, 61-4, (1991). View articlePMID: 2037074

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