Member database | Pfam |
Pfam type | domain |
Short name | TFIIE_beta |
Clan | HTH |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
General transcription factor TFIIE consists of two subunits, TFIIE alpha Pfam:PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved
[1] and has a winged helix fold.
References
1.Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface. Okuda M, Watanabe Y, Okamura H, Hanaoka F, Ohkuma Y, Nishimura Y. EMBO J. 19, 1346-56, (2000). View articlePMID: 10716934