Member database | Pfam |
Pfam type | domain |
Short name | TFIIE_beta |
Clan | HTH |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
General transcription factor TFIIE consists of two subunits, TFIIE alpha
PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved
[1] and has a winged helix fold.
References
1.Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface. Okuda M, Watanabe Y, Okamura H, Hanaoka F, Ohkuma Y, Nishimura Y. EMBO J. 19, 1346-56, (2000). View articlePMID: 10716934