PF02437

SKI/SNO/DAC family

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSki_Sno
ClanHTH
Author Mian N;0000-0003-4284-4749 Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation
[1]
. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development
[2, 3]
.

References

1.Cloning and expression of the axolotl proto-oncogene ski. Ludolph DC, Neff AW, Parker MA, Mescher AL, Smith RC, Malacinski GM. Biochim. Biophys. Acta 1260, 102-4, (1995). View articlePMID: 7999783

2.dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Mardon G, Solomon NM, Rubin GM. Development 120, 3473-86, (1994). View articlePMID: 7821215

3.The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sex-specifically in the genital imaginal disc. Keisman EL, Baker BS. Development 128, 1643-56, (2001). View articlePMID: 11290302

Further reading

4. Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb. Hammond KL, Hanson IM, Brown AG, Lettice LA, Hill RE. Mech. Dev. 74, 121-31, (1998). View articlePMID: 9651501

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