PF02760

HIN-200/IF120x domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameHIN
ClanOB
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This domain is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain Pfam:PF02758. This domain recognises and interacts with the phosphate backbone of dsDNA in a sequence-independent manner
[2, 1, 3]
.

References

1.Structural basis for termination of AIM2-mediated signaling by p202. Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. Cell Res 23, 855-8, (2013). PMID: 23567559

2.Structural mechanism of DNA recognition by the p204 HIN domain. Fan X, Jiang J, Zhao D, Chen F, Ma H, Smith P, Unterholzner L, Xiao TS, Jin T. Nucleic Acids Res 49, 2959-2972, (2021). PMID: 33619523

3.Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Immunity 36, 561-71, (2012). View articlePMID: 22483801

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.