Member database | Pfam |
Pfam type | family |
Short name | DDT |
Author | Iyer LM;0000-0002-4844-2022 Aravind L;0000-0003-0771-253X Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description
The DDT domain is named after (DNA binding homeobox and Different Transcription factors) and is approximately 60 residues in length
[1]. Along with the WHIM motifs, it comprises an entirely alpha helical module found in diverse eukaryotic chromatin proteins
[2]. Based on the structure of Ioc3, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins
[2][3]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes
[2]. In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket
[2].
References
1.DDT -- a novel domain in different transcription and chromosome remodeling factors. Doerks T, Copley R, Bork P. Trends Biochem. Sci. 26, 145-6, (2001). View articlePMID: 11246006
2.The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Aravind L, Iyer LM. Cell Cycle 11, 119-31, (2012). View articlePMID: 22186017
3.Structure and mechanism of the chromatin remodelling factor ISW1a. Yamada K, Frouws TD, Angst B, Fitzgerald DJ, DeLuca C, Schimmele K, Sargent DF, Richmond TJ. Nature 472, 448-53, (2011). View articlePMID: 21525927