PF02791

DDT domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameDDT
Author Iyer LM;0000-0002-4844-2022 Aravind L;0000-0003-0771-253X Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

The DDT domain is named after (DNA binding homeobox and Different Transcription factors) and is approximately 60 residues in length
[1]
. Along with the WHIM motifs, it comprises an entirely alpha helical module found in diverse eukaryotic chromatin proteins
[2]
. Based on the structure of Ioc3, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins
[2]
[3]
. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes
[2]
. In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket
[2]
.

References

1.DDT -- a novel domain in different transcription and chromosome remodeling factors. Doerks T, Copley R, Bork P. Trends Biochem. Sci. 26, 145-6, (2001). View articlePMID: 11246006

2.The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Aravind L, Iyer LM. Cell Cycle 11, 119-31, (2012). View articlePMID: 22186017

3.Structure and mechanism of the chromatin remodelling factor ISW1a. Yamada K, Frouws TD, Angst B, Fitzgerald DJ, DeLuca C, Schimmele K, Sargent DF, Richmond TJ. Nature 472, 448-53, (2011). View articlePMID: 21525927

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