PF02810

SEC-C motif

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSEC-C
ClanC4-like
Author Aravind L;0000-0003-0771-253X
Sequence Ontology0000417

Description

This SEC-C motif is found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif chelates zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif [1-2]. In SecA, this zinc binding domain is involved in binding to SecB
[1]
. This domain has been also predicted to be a potential nucleic acid binding domain.

References

1.Structural determinants of SecB recognition by SecA in bacterial protein translocation. Zhou J, Xu Z. Nat. Struct. Biol. 10, 942-7, (2003). View articlePMID: 14517549

Further reading

2. NMR structure of the C-terminal domain of SecA in the free state. Matousek WM, Alexandrescu AT. Biochim. Biophys. Acta 1702, 163-71, (2004). PMID: 15488768

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