PF02866

lactate/malate dehydrogenase, alpha/beta C-terminal domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameLdh_1_C
ClanLDH_C
Author Bateman A;0000-0002-6982-4660 Eddy SR;0000-0001-6676-4706 Griffiths-Jones SR;0000-0001-6043-807X
Sequence Ontology0000417

Description

L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.

References

1. Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD. Chapman AD, Cortes A, Dafforn TR, Clarke AR, Brady RL. J. Mol. Biol. 285, 703-12, (1999). View articlePMID: 10075524

Wikipedia

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