PF02907

Hepatitis C virus NS3 protease

Pfam entry
Member databasePfam
Pfam typedomain
Short namePeptidase_S29
ClanPeptidase_PA
Author Griffiths-Jones SR;0000-0001-6043-807X Knutson S;
Sequence Ontology0000417

Description

Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold. The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3. The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins. The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A.

References

1. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z. Cell 87, 331-42, (1996). View articlePMID: 8861916

2. Substrate specificity of the hepatitis C virus serine protease NS3. Urbani A, Bianchi E, Narjes F, Tramontano A, De Francesco R, Steinkuhler C, Pessi A. J. Biol. Chem. 272, 9204-9, (1997). View articlePMID: 9083052

3. Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M, Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z. Protein Sci. 7, 837-47, (1998). View articlePMID: 9568891

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