PF03492

SAM dependent carboxyl methyltransferase

Pfam entry
Member databasePfam
Pfam typefamily
Short nameMethyltransf_7
ClanNADP_Rossmann
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N. The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyses the second step to produce theobromine
[1]
.

References

1.7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties. Ogawa M, Herai Y, Koizumi N, Kusano T, Sano H. J. Biol. Chem. 276, 8213-8, (2001). View articlePMID: 11108716

Further reading

2. Jasmonic acid carboxyl methyltransferase: a key enzyme for jasmonate-regulated plant responses. Seo HS, Song JT, Cheong JJ, Lee YH, Lee YW, Hwang I, Lee JS, Choi YD. Proc. Natl. Acad. Sci. U.S.A. 98, 4788-93, (2001). View articlePMID: 11287667

3. Caffeine synthase gene from tea leaves. Kato M, Mizuno K, Crozier A, Fujimura T, Ashihara H. Nature 406, 956-7, (2000). View articlePMID: 10984041

4. Developmental regulation of methyl benzoate biosynthesis and emission in snapdragon flowers. Dudareva N, Murfitt LM, Mann CJ, Gorenstein N, Kolosova N, Kish CM, Bonham C, Wood K. Plant Cell 12, 949-61, (2000). View articlePMID: 10852939

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