PF03550

Outer membrane lipoprotein LolB

Pfam entry
Member databasePfam
Pfam typefamily
Short nameLolB
ClanLolA_LolB
AuthorTIGRFAMs; Griffiths-Jones SR;0000-0001-6043-807X
Sequence Ontology0100021

Description
Imported from IPR004565

This protein, LolB, is known so far only in the gamma subdivision of the Proteobacteria. It is a processed, lipid-modified outer membrane protein. In Escherichia coli, lipoproteins are anchored to the periplasmic side of either the inner or outer membrane through N-terminal lipids, depending on the lipoprotein-sorting signal present at position 2
[1]
. Five Lol proteins are involved in the sorting and outer membrane localization of lipoproteins. LolCDE, an ATP binding cassette (ABC) transporter, in the inner membrane releases outer membrane-directed lipoproteins from the inner membrane in an ATP-dependent manner, leading to the formation of a water-soluble complex between the lipoprotein and LolA. The LolA-lipoprotein complex crosses the periplasm and then interacts with outer membrane receptor LolB, which is essential for the anchoring of lipoproteins to the outer membrane.

References
Imported from IPR004565

1.Elucidation of the function of lipoprotein-sorting signals that determine membrane localization. Masuda K, Matsuyama S, Tokuda H. Proc. Natl. Acad. Sci. U.S.A. 99, 7390-5, (2002). View articlePMID: 12032293

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