PF03865

Haemolysin secretion/activation protein ShlB/FhaC/HecB

Pfam entry
Member databasePfam
Pfam typefamily
Short nameShlB
ClanMBB
Author Finn RD;0000-0001-8626-2148 Henderson I; Moxon SJ;0000-0003-4644-1816
Sequence Ontology0100021

Description

This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein
[1]
.

References

1.Activation of Serratia marcescens hemolysin through a conformational change. Walker G, Hertle R, Braun V. Infect. Immun. 72, 611-4, (2004). View articlePMID: 14688146

Further reading

2. Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins. Jacob-Dubuisson F, Locht C, Antoine R. Mol. Microbiol. 40, 306-13, (2001). View articlePMID: 11309114

3. Type V protein secretion: simplicity gone awry? Desvaux M, Parham NJ, Henderson IR. 6, 111-24, (2004). PMID: 15119822

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.