Member database | Pfam |
Pfam type | family |
Short name | Rpr2 |
Author | Kerrison ND;0000-0002-1471-953X Finn RD;0000-0001-8626-2148 Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526 |
Sequence Ontology | 0100021 |
Description
This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologues. This family includes SNM1
[2]. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically
[2]. This subunit possibly binds the precursor tRNA
[1].
References
1.Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. Jarrous N, Reiner R, Wesolowski D, Mann H, Guerrier-Takada C, Altman S. RNA 7, 1153-64, (2001). View articlePMID: 11497433
2.Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation. Cai T, Reilly TR, Cerio M, Schmitt ME. Mol. Cell. Biol. 19, 7857-69, (1999). View articlePMID: 10523674
Integrated to
Representative structure
1x0t: Crystal structure of ribonuclease P protein Ph1601p from Pyrococcus horikoshii OT3