PF04032

RNAse P Rpr2/Rpp21/SNM1 subunit domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameRpr2
Author Kerrison ND;0000-0002-1471-953X Finn RD;0000-0001-8626-2148 Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526
Sequence Ontology0100021

Description

This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologues. This family includes SNM1
[2]
. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically
[2]
. This subunit possibly binds the precursor tRNA
[1]
.

References

1.Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. Jarrous N, Reiner R, Wesolowski D, Mann H, Guerrier-Takada C, Altman S. RNA 7, 1153-64, (2001). View articlePMID: 11497433

2.Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation. Cai T, Reilly TR, Cerio M, Schmitt ME. Mol. Cell. Biol. 19, 7857-69, (1999). View articlePMID: 10523674

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