PF04055

Radical SAM superfamily

Pfam entry
Member databasePfam
Pfam typedomain
Short nameRadical_SAM
ClanTIM_barrel
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.

References

1. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification. Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O. J. Am. Chem. Soc. 129, 3462-3, (2007). View articlePMID: 17335281

2. Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Sofia HJ, Chen G, Hetzler BG, Reyes-Spindola JF, Miller NE. Nucleic Acids Res. 29, 1097-106, (2001). View articlePMID: 11222759

3. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. Berteau O, Guillot A, Benjdia A, Rabot S. J. Biol. Chem. 281, 22464-70, (2006). View articlePMID: 16766528

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