PF04352

ProQ/FINO family

Pfam entry
Member databasePfam
Pfam typedomain
Short nameProQ
Author Mifsud W;0000-0002-9805-6461 Moxon SJ;0000-0003-4644-1816 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

This family includes ProQ, which is required for full activation of the osmoprotectant transporter, ProP, in Escherichia coli. This family includes several bacterial fertility inhibition (FINO) proteins. The conjugative transfer of F-like plasmids is repressed by FinO, an RNA binding protein. FinO interacts with the F-plasmid encoded traJ mRNA and its antisense RNA, FinP, stabilising FinP against endonucleolytic degradation and facilitating sense-antisense RNA recognition
[2]
. ProQ operates as an RNA-chaperone, binding RNA and bringing about both RNA strand-exchange and RNA duplexing. This suggests that in fact it does not regulate ProP transcription but rather regulates ProP translation through activity as an RNA-binding protein
[1]
.

References

1.ProQ is an RNA chaperone that controls ProP levels in Escherichia coli. Chaulk SG, Smith Frieday MN, Arthur DC, Culham DE, Edwards RA, Soo P, Frost LS, Keates RA, Glover JN, Wood JM. Biochemistry 50, 3095-106, (2011). View articlePMID: 21381725

2.Crystal structure of the bacterial conjugation repressor finO. Ghetu AF, Gubbins MJ, Frost LS, Glover JN. Nat. Struct. Biol. 7, 565-9, (2000). View articlePMID: 10876242

Further reading

3. Protein ProQ influences osmotic activation of compatible solute transporter ProP in Escherichia coli K-12. Kunte HJ, Crane RA, Culham DE, Richmond D, Wood JM. J. Bacteriol. 181, 1537-43, (1999). View articlePMID: 10049386

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.