PF04539

Sigma-70 region 3

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSigma70_r3
ClanHTH
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0100021

Description

Region 3 forms a discrete compact three helical domain within the sigma-factor. Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role. Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme
[1]
.

References

1.Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Campbell EA, Muzzin O, Chlenov M, Sun JL, Olson CA, Weinman O, Trester-Zedlitz ML, Darst SA. Mol. Cell 9, 527-39, (2002). View articlePMID: 11931761

Wikipedia

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