Member database | Pfam |
Pfam type | family |
Short name | ApoC-I |
Clan | Apolipoprotein |
Author | Kerrison ND;0000-0002-1471-953X |
Sequence Ontology | 0100021 |
Description
Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway
[1]. ApoC-1 has been implicated in hypertriglyceridemia
[3], and Alzheimer's disease
[2].
References
1.Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study. Gursky O. Biochemistry 40, 12178-85, (2001). View articlePMID: 11580293
2.Apolipoprotein C-I expression in the brain in Alzheimer's disease. Petit-Turcotte C, Stohl SM, Beffert U, Cohn JS, Aumont N, Tremblay M, Dea D, Yang L, Poirier J, Shachter NS. Neurobiol. Dis. 8, 953-63, (2001). View articlePMID: 11741391
3.Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Shachter NS. Curr. Opin. Lipidol. 12, 297-304, (2001). View articlePMID: 11353333
Integrated to
Representative structure
6dvu: Structure of the Monoclinic-1 (Monocl-1) Crystal Form of Human Apolipoprotein C1