PF04715

Anthranilate synthase component I, N terminal region

Pfam entry
Member databasePfam
Pfam typefamily
Short nameAnth_synt_I_N
Author Kerrison ND;0000-0002-1471-953X
Sequence Ontology0100021

Description

Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan
[1]
. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).

References

1.The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. Proc. Natl. Acad. Sci. U.S.A. 98, 6021-6, (2001). View articlePMID: 11371633

Further reading

2. A metabolic node in action: chorismate-utilizing enzymes in microorganisms. Dosselaere F, Vanderleyden J. Crit. Rev. Microbiol. 27, 75-131, (2001). PMID: 11450855

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