PF04727

ELMO/CED-12 family

Pfam entry
Member databasePfam
Pfam typefamily
Short nameELMO_CED12
Author Mifsud W;0000-0002-9805-6461
Sequence Ontology0100021

Description

This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells
[1]
. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.

References

1.CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS. Cell 107, 27-41, (2001). View articlePMID: 11595183

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