Member database | Pfam |
Pfam type | domain |
Short name | Sec23_trunk |
Clan | vWA-like |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
References
1. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. Proc. Natl. Acad. Sci. U.S.A. 98, 10704-9, (2001). View articlePMID: 11535824