PF04998

RNA polymerase Rpb1, domain 5

Pfam entry
Member databasePfam
Pfam typedomain
Short nameRNA_pol_Rpb1_5
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound
[2, 1]
.

References

1.Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer P, Bushnell DA, Kornberg RD. Science 292, 1863-76, (2001). View articlePMID: 11313498

2.Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. Severinov K, Mustaev A, Kukarin A, Muzzin O, Bass I, Darst SA, Goldfarb A. J. Biol. Chem. 271, 27969-74, (1996). View articlePMID: 8910400

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