Member database | Pfam |
Pfam type | domain |
Short name | SUFU |
Clan | Sufu_N |
Author | Moxon SJ;0000-0003-4644-1816 |
Sequence Ontology | 0000417 |
Description
SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus
[1]. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway
[3]. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems
[2].
References
1.Medulloblastoma: a problem of developmental biology. Rubin JB, Rowitch DH. Cancer Cell 2, 7-8, (2002). View articlePMID: 12150819
2.A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. Zhang D, Iyer LM, Aravind L. Nucleic Acids Res. 39, 4532-52, (2011). View articlePMID: 21306995
3.Mutations in SUFU predispose to medulloblastoma. Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM, Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka JT, Hogg D. Nat. Genet. 31, 306-10, (2002). View articlePMID: 12068298
Integrated to
Representative structure
6lph: the Sufu-Fu complex crystal structure