PF05133

Phage portal protein, SPP1 Gp6-like

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSPP1_portal
ClanPhage_portal
AuthorTIGRFAMs; Finn RD;0000-0001-8626-2148
Sequence Ontology0100021

Description

This bacteriophage protein forms a gateway that enables DNA passage during packaging and ejection of the phage genome. It also forms the junction between the phage head (capsid) and the tail proteins. During SPP1 morphogenesis, the portal protein, Gp6, participates in the procapsid assembly reaction
[3, 2]
. In the mature SPP1 virion, Gp6 exists as a dodecamer, while recombinant SPP1 Gp6 has been shown to form 13-subunit assemblies
[3, 1]
. This protein is common to Siphoviridae (phages with long non-contractile tails) and Myoviridae (phages with contractile tails). It is also found in a number of bacterial species. This family also includes the old Pfam family Phage_min_cap (PF:PF05126). RC Paper describing PDB structure 2jes

References

1.Structural framework for DNA translocation via the viral portal protein. Lebedev AA, Krause MH, Isidro AL, Vagin AA, Orlova EV, Turner J, Dodson EJ, Tavares P, Antson AA. EMBO J. 26, 1984-94, (2007). View articlePMID: 17363899

2.Structural rearrangements in the phage head-to-tail interface during assembly and infection. Chaban Y, Lurz R, Brasiles S, Cornilleau C, Karreman M, Zinn-Justin S, Tavares P, Orlova EV. Proc. Natl. Acad. Sci. U.S.A. 112, 7009-14, (2015). View articlePMID: 25991862

3.Structural organisation of the head-to-tail interface of a bacterial virus. Lurz R, Orlova EV, Gunther D, Dube P, Droge A, Weise F, van Heel M, Tavares P. J. Mol. Biol. 310, 1027-37, (2001). View articlePMID: 11501993

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