PF05279

Aspartyl beta-hydroxylase N-terminal region

Pfam entry
Member databasePfam
Pfam typefamily
Short nameAsp-B-Hydro_N
Author Moxon SJ;0000-0003-4644-1816
Sequence Ontology0100021

Description

This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin
[2]
. Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins
[1]
.

References

1.Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA. J. Biol. Chem. 277, 12970-7, (2002). View articlePMID: 11773073

2.Molecular cloning and characterization of mouse cardiac junctate isoforms. Hong CS, Kwak YG, Ji JH, Chae SW, Kim DH. Biochem. Biophys. Res. Commun. 289, 882-7, (2001). View articlePMID: 11735129

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