PF05424

Duffy binding domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameDuffy_binding
ClanDBL
Author Moxon SJ;0000-0003-4644-1816 Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa
[1]
. This family is closely associated on PfEMP1 proteins with PFEMP, Pfam:PF03011.

References

1.The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites. Adams JH, Hudson DE, Torii M, Ward GE, Wellems TE, Aikawa M, Miller LH. Cell 63, 141-53, (1990). View articlePMID: 2170017

Further reading

2. Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Lavstsen T, Salanti A, Jensen AT, Arnot DE, Theander TG. Malar. J. 2, 27, (2003). View articlePMID: 14565852

3. Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer. Rask TS, Hansen DA, Theander TG, Gorm Pedersen A, Lavstsen T. PLoS Comput. Biol. 6, 3985-97, (2010). View articlePMID: 20862303

4. Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L. Cell 122, 183-93, (2005). View articlePMID: 16051144

5. Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition. Juillerat A, Lewit-Bentley A, Guillotte M, Gangnard S, Hessel A, Baron B, Vigan-Womas I, England P, Mercereau-Puijalon O, Bentley GA. Proc. Natl. Acad. Sci. U.S.A. 108, 5243-8, (2011). View articlePMID: 21402930

Wikipedia

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