Member database | Pfam |
Pfam type | domain |
Short name | Toxin_6 |
Clan | Knottin_1 |
Description
This family consists of toxin-like peptides that are isolated from the venom of Buthus martensii Karsch scorpion. The precursor consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -Stabilised alphabeta (CSalphabeta) motif
[2]. This family acts by blocking small conductance calcium activated potassium ion channels in their victim
[3, 1].
References
1.Molecular cloning and sequencing of two 'short chain' and two 'long chain' K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. Zhu S, Li W, Zeng X, Jiang D, Mao X, Liu H. FEBS Lett. 457, 509-14, (1999). View articlePMID: 10471839
2.Precursor nucleotide sequence and genomic organization of BmTXKS1, a new scorpion toxin-like peptide from Buthus martensii Karsch. Zhu SY, Li WX, Zeng XC. Toxicon 39, 1291-6, (2001). View articlePMID: 11384716
3.Solution structure of BmP02, a new potassium channel blocker from the venom of the Chinese scorpion Buthus martensi Karsch. Xu Y, Wu J, Pei J, Shi Y, Ji Y, Tong Q. Biochemistry 39, 13669-75, (2000). View articlePMID: 11076505