PF06201

PITH domain

Pfam entry
Member databasePfam
Pfam typedomain
Short namePITH
ClanGBD
Author Yeats C;0000-0003-0080-6242
Sequence Ontology0000417

Description

This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.

References

1. Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. Andersen KM, Madsen L, Prag S, Johnsen AH, Semple CA, Hendil KB, Hartmann-Petersen R. J. Biol. Chem. 284, 15246-54, (2009). View articlePMID: 19349277

2. Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein. Song J, Tyler RC, Wrobel RL, Frederick RO, Vojtek FC, Jeon WB, Lee MS, Markley JL. Protein Sci. 14, 1059-63, (2005). View articlePMID: 15741346

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