PF06446

Hepcidin

Pfam entry
Member databasePfam
Pfam typedomain
Short nameHepcidin
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description

Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin
[1]
.

References

1.The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. Hunter HN, Fulton DB, Ganz T, Vogel HJ. J. Biol. Chem. 277, 37597-603, (2002). View articlePMID: 12138110

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