Member database | Pfam |
Pfam type | domain |
Short name | Hepcidin |
Author | Finn RD;0000-0001-8626-2148 |
Sequence Ontology | 0000417 |
Description
Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin
[1].
References
1.The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. Hunter HN, Fulton DB, Ganz T, Vogel HJ. J. Biol. Chem. 277, 37597-603, (2002). View articlePMID: 12138110