Member database | Pfam |
Pfam type | repeat |
Short name | COPI_C |
Clan | TPR |
Author | Vella Briffa B;0000-0003-4380-1783 |
Sequence Ontology | 0001068 |
Description
This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport
[1]. Note that many family members also contain the Pfam:PF04053 domain.
References
1.Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting. Cosson P, Letourneur F. Curr. Opin. Cell Biol. 9, 484-7, (1997). View articlePMID: 9261053
Further reading
2. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, Hoelz A. Proc. Natl. Acad. Sci. U.S.A. 107, 11271-6, (2010). View articlePMID: 20534429