PF06957

Coatomer (COPI) alpha subunit C-terminus

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameCOPI_C
ClanTPR
Author Vella Briffa B;0000-0003-4380-1783
Sequence Ontology0001068

Description

This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport
[1]
. Note that many family members also contain the Pfam:PF04053 domain.

References

1.Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting. Cosson P, Letourneur F. Curr. Opin. Cell Biol. 9, 484-7, (1997). View articlePMID: 9261053

Further reading

2. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, Hoelz A. Proc. Natl. Acad. Sci. U.S.A. 107, 11271-6, (2010). View articlePMID: 20534429

Wikipedia

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