PF07039

SGF29 tudor-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSGF29_Tudor
ClanSH3
Author Moxon SJ;0000-0003-4644-1816 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

SAGA-associated factor 29 (SGF29) is involved in transcriptional regulation as a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes
[4, 3, 2, 1, 5]
. It specifically recognises and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for the trimethylated form (H3K4me3). It also may be involved in MYC-mediated oncogenic transformation
[4]
. This entry represents the two tandem tudor-like domains found at the C-terminal of yeast and human SGF29 proteins and the plant homologues. Each of them has a negatively-charged pocket capable of binding H3A1 and an aromatic cage for the recognition of H3K4me2/3 residues
[2, 1]
.

References

1.Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL, Zang J, Min J. EMBO J. 30, 2829-42, (2011). View articlePMID: 21685874

2.The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. Pieters BJ, Meulenbroeks E, Belle R, Mecinovic J. PLoS One 10, e0139205, (2015). PMID: 26421618

3.Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Cell 142, 967-80, (2010). View articlePMID: 20850016

4.The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J. Mol. Cell. Biol. 29, 1176-88, (2009). View articlePMID: 19103755

5.Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins. Kamps JJ, Huang J, Poater J, Xu C, Pieters BJ, Dong A, Min J, Sherman W, Beuming T, Matthias Bickelhaupt F, Li H, Mecinovic J. Nat Commun 6, 8911, (2015). PMID: 26578293

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