PF07474

G2F domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameG2F
ClanGFP
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein Pfam:PF01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.

References

1. Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1. Hopf M, Gohring W, Ries A, Timpl R, Hohenester E. Nat. Struct. Biol. 8, 634-40, (2001). View articlePMID: 11427896

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