PF07521

Zn-dependent metallo-hydrolase RNA specificity domain

Pfam entry
Member databasePfam
Pfam typeconserved site
Short nameRMMBL
ClanRMMBL_DRMBL
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0001067

Description

The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases. This, the fifth motif
[3]
, appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2
[4]
which are involved in the processing of mRNA
[1, 2]
. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases
[1, 2, 4]
.

References

1.Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. Nature 444, 953-6, (2006). View articlePMID: 17128255

2.Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii. Nishida Y, Ishikawa H, Baba S, Nakagawa N, Kuramitsu S, Masui R. Proteins 78, 2395-8, (2010). View articlePMID: 20544974

3.Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Callebaut I, Moshous D, Mornon JP, de Villartay JP. Nucleic Acids Res. 30, 3592-601, (2002). View articlePMID: 12177301

4.Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex. Roux CM, DeMuth JP, Dunman PM. J. Bacteriol. 193, 5520-6, (2011). View articlePMID: 21764917

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