Member database | Pfam |
Pfam type | domain |
Short name | M20_dimer |
Author | Bateman A;0000-0002-6982-4660 Studholme DJ;0000-0002-3010-6637 |
Sequence Ontology | 0000417 |
Description
This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases
[2]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification
[1]. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.
References
1.Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 248, 183-228, (1995). View articlePMID: 7674922
2.Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy. Rowsell S, Pauptit RA, Tucker AD, Melton RG, Blow DM, Brick P. Structure 5, 337-47, (1997). View articlePMID: 9083113