PF07687

Peptidase dimerisation domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameM20_dimer
Author Bateman A;0000-0002-6982-4660 Studholme DJ;0000-0002-3010-6637
Sequence Ontology0000417

Description

This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases
[2]
. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification
[1]
. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.

References

1.Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 248, 183-228, (1995). View articlePMID: 7674922

2.Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy. Rowsell S, Pauptit RA, Tucker AD, Melton RG, Blow DM, Brick P. Structure 5, 337-47, (1997). View articlePMID: 9083113

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.