PF07780

Spb1 C-terminal domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSpb1_C
Author Fenech M;0000-0001-7933-4617 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

This domain is found at the C-terminus of a family of FtsJ-like methyltransferases. Members of this family are involved in 60S ribosomal biogenesis, for example Swiss:P25582
[2]
. This domain interacts with the meandering tail of Erb1 and its removal is required to form the pre-mature inter-subunit surface of the Arx1/Nog2 particle
[2, 1]
.

References

1.Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R. Cell 171, 1599-1610.e14, (2017). PMID: 29245012

2.Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Kressler D, Rojo M, Linder P, Cruz J. Nucleic Acids Res. 27, 4598-608, (1999). View articlePMID: 10556316

Further reading

3. Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Kater L, Mitterer V, Thoms M, Cheng J, Berninghausen O, Beckmann R, Hurt E. Mol Cell 79, 615-628.e5, (2020). PMID: 32668200

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