PF07798

Coiled-coil domain-containing protein 90-like

Pfam entry
Member databasePfam
Pfam typefamily
Short nameCCDC90-like
Author Fenech M;0000-0001-7933-4617
Sequence Ontology0100021

Description

This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1
[1, 4, 3]
. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU
[5]
, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU
[1, 2]
. The role of CCDC90B proteins is still not known.

References

1.MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jana F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M. Cell Rep 15, 1673-85, (2016). PMID: 27184846

2.MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter. Vais H, Tanis JE, Muller M, Payne R, Mallilankaraman K, Foskett JK. Cell Metab 22, 533-5, (2015). PMID: 26445506

3.Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Proc Natl Acad Sci U S A 113, E1872-80, (2016). PMID: 26976564

4.MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Mallilankaraman K, Cardenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenar T, Csordas G, Madireddi P, Yang J, Muller M, Miller R, Kolesar JE, Molgo J, Kaufman B, Hajnoczky G, Foskett JK, Madesh M. Nat. Cell Biol. 14, 1336-43, (2012). View articlePMID: 23178883

5.CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter. Paupe V, Prudent J, Dassa EP, Rendon OZ, Shoubridge EA. Cell Metab. 21, 109-16, (2015). View articlePMID: 25565209

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